Release Notes🔗
Apheris Hub 1.0.0🔗
- Release date: 2025-08-08
Application Manager version: 0.2.0🔗
Co-folding application: 0.9.0🔗
- Boltz-2
boltz2:0.9.0-private-msaboltz2:0.9.0-public-msa
- Mock Model
mock:0.9.0-private-msamock:0.9.0-public-msa
- OpenFold 3
openfold3:0.9.0-private-msaopenfold3:0.9.0-public-msa
Highlights🔗
The Apheris Hub provides local access to AI-based drug discovery applications. Applications deployed in the Apheris Hub are designed to run entirely locally or in your private cloud or on-prem environments - such that no data ever leaves your environment. They integrate into enterprise R&D stacks and extend rather than replace existing scientific workflows.
Applications in the Apheris Hub focus on a set of drug discovery tasks and are based on one or more foundation models.
Our first application is focused on Co-Folding, starting with inference - including input validation, and batch execution either programmatically via an API or manually with a scientist-friendly GUI.
The Apheris Co‑Folding Application is a secure, locally hosted tool for using co‑folding models on sensitive proprietary data. By running Boltz-2 and OpenFold3 on in‑house targets, researchers can assess model accuracy in their specific domain and easily integrate these models into their wider workflows. The product provides visualization tools, streamlined data preparation support, and generates auditable, reproducible records for use in regulated environments.
Upcoming Improvements🔗
Our first release is designed to support early evaluation and adoption of OpenFold3, and we are already making many improvements for follow-up releases. We are investing in more powerful visualizations, more models, job management, and supporting fine-tuning locally and via secure federation.
We plan to release additional support for data preparation, benchmarking, and fine-tuning in our early pipeline. We can already support integrating these models into your existing benchmarking pipelines, but we'd like to add more to ensure the biggest impact on your benchmarking efforts. We'd love to hear any feedback you have around this as well. Please feel free to reach out with feature requests, comments, or suggestions at support@apheris.com.
In future versions, we will allow pointing to an existing private MSA server for OpenFold3. However, today Apheris can also help you set up a private MSA server if you wish. In that case, please contact us at support@apheris.com.
For the first release, submitting additional jobs will put those jobs in a queue. The GPU is fully consumed per job; parallelism and multi-GPU support will come with follow-up releases. The current architecture was built for simplicity in deployment and configuration with more flexibility and scalability coming very soon.