Rosemary Huckvale

Medicinal Chemist

Rosemary works on integrating co-folding capabilities into workflows of computational and medicinal chemists. She studied chemistry at the University of Oxford and completed her PhD in synthetic chemistry at University College London before training as a medicinal chemist. She has held roles at The Institute of Cancer Research, Healx, and CHARM Therapeutics, contributing to early discovery and compound design.

View LinkedIn profile

Articles by

Rosemary Huckvale

Co-folding models in lead optimization workflows

Co-folding models help lead optimization by predicting binding modes, filtering weak candidates before synthesis, and improving compound prioritization through benchmarking, fine-tuning, and expert review.

Mar 2026

Read the article

When does protein–ligand co-folding become useful in real medicinal chemistry?

Using a recent J. Med. Chem. TrmD study, we evaluate how well OpenFold3 protein–ligand co-folding recovers binding modes and key interactions, and where it can realistically support medicinal chemistry decisions.

Feb 2026

Read the article